Brain damage and death from ischemic encephalopathy is common after cardiac arrest. Animal studies and limited observational studies suggest that high oxygen exposure after ROSC may result in neuronal death. As such, it is hypothesized that limiting oxygen exposure (conservative oxygen) many attenuate reperfusion injury and improve outcomes. At present, analyses from 2 trials in patients with cardiac arrest in the ICU suggested a benefit with conservative oxygen therapy. In contrast, a trial of cardiac arrest patients in Denmark showed no difference in outcomes between conservative and liberal oxygen strategies (the BOX trial). In this podcast, we review the LOGICAL Trial, the latest study to compare conservative and liberal oxygen therapy in post-cardiac arrest patients.
Several recent articles have challenged the long-held belief that we should treat fever in patients with sepsis? In this episode we review these recent...
Many critically ill patients are acidotic. Often, bicarbonate is administered to severely acidotic patients, but does it really improve outcomes? The BICAR-ICU was just...
Up to 25% of critically ill patients who undergo RSI and endotracheal intubation (ETI) may suffer cardiovascular collapse.? Many clinicians administer IVFs during RSI...