Timely administration of broad-spectrum antibiotics is a critical pillar in the resuscitation of patients with sepsis. B-lactam antibiotics are an important class of antibiotics commonly administered to patients with sepsis. Typically, B-lactam antibiotics are administered over 30 minutes, but optimal bactericidal activity requires the concentration of free drug to be above the MIC of the organism for 40-70% of the dosing interval. In this podcast we discuss two recent publications that compare continuous infusions of B-lactam antibiotics with intermittent effusions in patients with sepsis.
More than 1.5 million patients are intubated each year in the United States. In up to 20% of patients, the first attempt at intubation...
To say that 2020 has been a challenging year would be a gross understatement. The courage and determination that all healthcare providers have shown...
Acute aortic syndromes such as aortic dissection are incredibly stressful and challenging to manage. In this episode, we tackle the difficult management pearls and...