Continuous or Intermittent B-Lactam Infusions for Sepsis?

September 24, 2024 00:29:51
Continuous or Intermittent B-Lactam Infusions for Sepsis?
Critical Care Perspectives in Emergency Medicine
Continuous or Intermittent B-Lactam Infusions for Sepsis?

Sep 24 2024 | 00:29:51

/

Show Notes

Timely administration of broad-spectrum antibiotics is a critical pillar in the resuscitation of patients with sepsis.  B-lactam antibiotics are an important class of antibiotics commonly administered to patients with sepsis.  Typically, B-lactam antibiotics are administered over 30 minutes, but optimal bactericidal activity requires the concentration of free drug to be above the MIC of the organism for 40-70% of the dosing interval.  In this podcast we discuss two recent publications that compare continuous infusions of B-lactam antibiotics with intermittent effusions in patients with sepsis.

Other Episodes

Episode

December 05, 2024 00:25:46
Episode Cover

High-Intensity NIPPV for Acute COPD Exacerbations?

NIPPV is frequently used in the management of critically ill patients presenting with an acute COPD exacerbation, as NIPPV decreases the rates of intubation...

Listen

Episode 0

February 09, 2023 00:25:24
Episode Cover

Should We Use a Liberal or Restrictive Fluid Strategy in Sepsis - The CLOVERS Trial

Intravenous fluid (IVF) administration is a central tenet to the resuscitation of patients with sepsis and sepsis-induced hypotension.  At present, the administration of large...

Listen

Episode 0

June 17, 2022 00:37:25
Episode Cover

Life-Threatening Asthma

Approximately 2 million patients present each year to EDs in the United States for acute asthma exacerbations.  Of these, up to 50,000 may require...

Listen