Timely administration of broad-spectrum antibiotics is a critical pillar in the resuscitation of patients with sepsis. B-lactam antibiotics are an important class of antibiotics commonly administered to patients with sepsis. Typically, B-lactam antibiotics are administered over 30 minutes, but optimal bactericidal activity requires the concentration of free drug to be above the MIC of the organism for 40-70% of the dosing interval. In this podcast we discuss two recent publications that compare continuous infusions of B-lactam antibiotics with intermittent effusions in patients with sepsis.
The emergency department resuscitation of patients with sepsis focuses on early recognition, timely administration of appropriate antibiotics, appropriate fluid resuscitation, early vasopressor initiation for...
Hyponatremia is one of the most common electrolyte disorders encountered in emergency medicine and critical care. Patients with hyponatremic encephalopathy represent a severe form...
Rory Spiegel and Ken Butler join the podcast to discuss critical issues in intubating and ventilating the obese patient. What physiologic changes do you...