Continuous or Intermittent B-Lactam Infusions for Sepsis?

September 24, 2024 00:29:51
Continuous or Intermittent B-Lactam Infusions for Sepsis?
Critical Care Perspectives in Emergency Medicine
Continuous or Intermittent B-Lactam Infusions for Sepsis?

Sep 24 2024 | 00:29:51

/

Show Notes

Timely administration of broad-spectrum antibiotics is a critical pillar in the resuscitation of patients with sepsis.  B-lactam antibiotics are an important class of antibiotics commonly administered to patients with sepsis.  Typically, B-lactam antibiotics are administered over 30 minutes, but optimal bactericidal activity requires the concentration of free drug to be above the MIC of the organism for 40-70% of the dosing interval.  In this podcast we discuss two recent publications that compare continuous infusions of B-lactam antibiotics with intermittent effusions in patients with sepsis.

Other Episodes

Episode 0

January 25, 2023 00:45:25
Episode Cover

Top Critical Care Articles of 2022

Given the increase in critically ill patients who present to the ED in need of resuscitation, along with the increase in those who board...

Listen

Episode 0

June 24, 2019 00:26:09
Episode Cover

Anticoagulation Reversal for ICH

ICH accounts for approximately 15 percent of all strokes.  Despite improvements in neurocritical care, the mortality for patients with ICH can still reach 50...

Listen

Episode

January 27, 2017 00:24:56
Episode Cover

The Complicated Alcohol Withdrawal Patient

Bryan Hayes is back!  In this podcast, we discuss pitfalls in the use of benzodiazpines along with current evidence on adjunctive treatments including propofol,...

Listen