Continuous or Intermittent B-Lactam Infusions for Sepsis?

September 24, 2024 00:29:51
Continuous or Intermittent B-Lactam Infusions for Sepsis?
Critical Care Perspectives in Emergency Medicine
Continuous or Intermittent B-Lactam Infusions for Sepsis?

Sep 24 2024 | 00:29:51

/

Show Notes

Timely administration of broad-spectrum antibiotics is a critical pillar in the resuscitation of patients with sepsis.  B-lactam antibiotics are an important class of antibiotics commonly administered to patients with sepsis.  Typically, B-lactam antibiotics are administered over 30 minutes, but optimal bactericidal activity requires the concentration of free drug to be above the MIC of the organism for 40-70% of the dosing interval.  In this podcast we discuss two recent publications that compare continuous infusions of B-lactam antibiotics with intermittent effusions in patients with sepsis.

Other Episodes

Episode 0

March 31, 2022 00:20:50
Episode Cover

The PLUS Study

Though we’ve discussed the use of balanced solutions in the resuscitation of critically ill patients numerous times on CCPEM, the literature remains controversial with...

Listen

Episode 0

October 26, 2021 00:26:40
Episode Cover

Vasopressin and Steroids for IHCA?

In 2009 and 2013 investigators published studies that demonstrated improved outcomes in patients with IHCA who received vasopressin and steroids in addition to epinephrine. ...

Listen

Episode 0

May 03, 2018 00:44:19
Episode Cover

A Clean Kill? Ventilating the Asthmatic Patient

Mechanically ventilating the patient with a severe asthma exacerbation is fraught with peril.  Incorrect settings for tidal volume, respiratory rate, pressure triggers, or inspiratory...

Listen